Venous Leg Ulcers (VLUs)

A venous ulcer tends to occur on the medial side of the leg, typically around the medial malleolus in the ‘gaiter area’ whereas tends to occur on lateral side of the leg and over bony prominences. A venous ulcer is typically shallow with irregular sloping edges whereas an arterial ulcer can be deep and has a ‘punched out’ appearance. Venous ulcers are typically ‘wet’ with a moderate to heavy exudate, whereas arterial ulcers are typically ‘dry’ and scabbed. The skin surrounding a venous ulcer may be edematous (swollen) and there may be evidence of varicose veins; the skin surrounding an arterial ulcer may be pale, cold, shiny and hairless. Both venous and arterial ulcers may be painful, however arterial ulcers tend to be more painful, especially with elevation of the leg, for example when in bed.


Diabetic Foot

A diabetic foot is a foot that exhibits any pathology that results directly from diabetes mellitus or any long-term (or “chronic”) complication of diabetes mellitus. Presence of several characteristic diabetic foot pathologies such as infection, diabetic foot ulcer and neuropathic osteoarthropathy is called diabetic foot syndrome.

Due to the peripheral nerve dysfunction associated with diabetes (diabetic neuropathy), patients have a reduced ability to feel pain. This means that minor injuries may remain undiscovered for a long while. People with diabetes are also at risk of developing a diabetic foot ulcer. Research estimates that the lifetime incidence of foot ulcers within the diabetic community is around 15% and may become as high as 25%.

In diabetes, peripheral nerve dysfunction can be combined with peripheral artery disease (PAD) causing poor blood circulation to the extremities (diabetic angiopathy). Around half of patients with a diabetic foot ulcer have co-existing PAD.

Where wounds take a long time to heal, infection may set in and lower limb amputation may be necessary. Foot infection is the most common cause of non-traumatic amputation in people with diabetes.


Diabetic Foot Ulcers (DFUs)

Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot.

Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process. Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting. Surgery in some cases may improve outcomes. Hyperbaric oxygen therapy may also help but is expensive.

It occurs in 15% of people with diabetes, and precedes 84% of all diabetes-related lower-leg amputations.


Peripheral Neuropathy

Diabetic neuropathy affects all peripheral nerves including sensory neurons, motor neurons, but rarely affects the autonomic nervous system. Therefore, diabetic neuropathy can affect all organs and systems, as all are innervated. There are several distinct syndromes based on the organ systems and members affected, but these are by no means exclusive. A patient can have sensorimotor and autonomic neuropathy or any other combination. Signs and symptoms vary depending on the nerve(s) affected and may include symptoms other than those listed. Symptoms usually develop gradually over years.

Symptoms may include the following:

  • Trouble with balance
  • Numbness and tingling of extremities
  • Dysesthesia (abnormal sensation to a body part)
  • Diarrhea
  • Erectile dysfunction
  • Urinary incontinence (loss of bladder control)
  • Facial, mouth and eyelid drooping
  • Vision changes
  • Dizziness
  • Muscle weakness
  • Difficulty swallowing
  • Speech impairment
  • Fasciculation (muscle contractions)
  • Burning or electric pain
An estimated 550 million people will be diagnosed worldwide by 2030.
Diabetes is a worldwide catastrophe currently affecting approximately 29 million people in the United States.
An individual suffering from diabetes has a 1-in-4 chance of developing a wound over the course of their lifetime.
Greater than 50% of all wounds become infected and approximately 20% of all infected wounds of the lower extremity lead to amputation.
There are currently 6.5 million patients in the United States who require wound care on a regular basis.